PathwayStep803 PathwayStep560 PathwayStep729 PathwayStep767 PathwayStep766 PathwayStep765 PathwayStep764 PathwayStep769 PathwayStep768 PathwayStep763 PathwayStep762 PathwayStep761 PathwayStep760 PathwayStep770 PathwayStep771 PathwayStep758 PathwayStep757 PathwayStep759 PathwayStep754 PathwayStep753 PathwayStep756 PathwayStep755 PathwayStep786 PathwayStep792 protein C -> activated protein C + protein C heavy chain activation peptide Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen Cell surface interactions at the vascular wall Authored: Ouwehand, W.H., 2007-11-12 16:45:54 GENE ONTOLOGYGO:0050900 Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.<p> Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.<p> This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury. Pubmed10798271 Pubmed11282294 Pubmed14615387 Pubmed16115029 Pubmed17525755 Pubmed8578462 Reactome Database ID Release 43202733 Reactome, http://www.reactome.org ReactomeREACT_12051 Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00 PECAM1 interactions Tie2 Signaling Basigin interactions VLA-4 binds JAM-B JAM-A homodimerises MAC1 binds JAM-C JAM-B binds JAM-C LFA1 binds JAM-A Integrin alphaXbeta2 binds JAM-C MERTK receptor binds ligands (Gas6 or Protein S) JAM-C homodimerises JAM-B homodimerises P-selectin binds P-selectin ligand CD84 homodimerises Integrin alpha 5 beta 1 binds fibronectin CD47 binds SIRP CD177 binds PECAM-1 CD58 binds CD2 CD48 binds CD244 Platelet-derived TREM-1 ligand binds to TREM-1 CXADR binds to AMICA1 OLR1 binds to oxidized LDL