PathwayStep776 PathwayStep775 PathwayStep778 PathwayStep777 PathwayStep779 PathwayStep772 PathwayStep774 PathwayStep773 PathwayStep782 PathwayStep783 PathwayStep784 PathwayStep785 PathwayStep780 PathwayStep781 Tie2 Signaling Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56 Pubmed11191051 Pubmed11566266 Pubmed11969368 Pubmed9764820 Reactome Database ID Release 43210993 Reactome, http://www.reactome.org ReactomeREACT_12621 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.<br>These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation. Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) Interaction of SOS-1 to Tie2 bound Grb2 Interaction of Tie2 and Grb2 Interaction of Tie2 and p85 of PI3K Interaction of Tie2 and Grb7 Interaction of Tie2 and Grb14 Interaction of Tie2 and Ang4 Interaction of Tie2 and Shp2 Interaction of Tie2 and Dok-2 Interaction of Tie2 with Ang2 Interaction of Tie2 and Shc1 Interaction of Tie2 with Ang1 Dimerization of Tie2/Ang1 complex Trans-phosphorylation of Tie2