PathwayStep801 PathwayStep802 PathwayStep800 PathwayStep795 PathwayStep796 PathwayStep793 PathwayStep794 PathwayStep799 PathwayStep797 PathwayStep798 Basigin interactions Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 Basigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interactions involved in various immunologic phenomena, differentiation, and development, but a major function of basigin is stimulation of synthesis of several matrix metalloproteinases. Basigin also induces angiogenesis via stimulation of VEGF production.<br>Basigin has an extracellular region with two Ig-like domains of which the N-term Ig-like domain is involved in interactions. It undergoes interactions between basigin molecules on opposing cells or on neighbouring cells. It also interacts with a variety of other proteins like caveolin-1, cyclophilins, integrins and annexin II that play important roles in cell proliferation, energy metabolism, migration, adhesion and motion, especially in cancer metastasis. Edited: Garapati, P V, 2009-03-16 17:55:42 Pubmed17700972 Reactome Database ID Release 43210991 Reactome, http://www.reactome.org ReactomeREACT_12560 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Basigin binds to integrins Basigin binds Mannose-carrying cell recognition molecules Basigin binds MCT1, MCT3 and MCT4 Basigin binds CD98 complex CyP60 chaperones Basigin Basigin homodimerises Caveolin-1 binds Basigin Basigin binds CyPA Basigin interacts with CD43 Basigin binds Matrix metalloproteinase-1