PathwayStep656 PathwayStep659 PathwayStep658 PathwayStep660 Thrombin binding to GP1b:IX:V Thrombopoietin binds the thrombopoietin receptor Platelet Aggregation (Plug Formation) Authored: de Bono, B, 2004-08-13 07:29:26 Pubmed17585075 Pubmed18174460 Reactome Database ID Release 4376009 Reactome, http://www.reactome.org ReactomeREACT_278 The tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment of others onto their surface leads to the formation of large platelet aggregates. The formation of a thrombus is strictly dependent on the formation of interplatelet bonds. Adrenaline signalling through Alpha-2 adrenergic receptor Integrin alphaIIb beta3 signaling