PathwayStep468 DNA Replication Pre-Initiation M/G1 Transition Finally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which is regulated by a large E3 ubiquitin ligase complex known as the Anaphase Promoting Complex (APC).<p>The detailed annotation of the M/G1 transition will be completed in a later version of GK. GENE ONTOLOGYGO:0000216 Reactome Database ID Release 4368874 Reactome, http://www.reactome.org ReactomeREACT_1725 Reviewed: Manfredi, J, 0000-00-00 00:00:00