'AGER ligands:AGER [plasma membrane]' positively regulates 'Released NFkB complex is transported to nucleus' ACTIVATION Pubmed11723063 Reactome Database ID Release 43879381 Reactome, http://www.reactome.org ReactomeREACT_24911 Though the signaling cascade is unclear, several pieces of experimental data suggest that activation of AGER leads to sustained activation and upregulation of NFkappaB, measured as NFkappaB translocation to the nucleus, and increased levels of de novo synthesized NFkappaB. Released NFkB complex is transported to nucleus AGER ligands:AGER