mRNA Transcript Targeted by AUF1(hnRNP D0) AUF1 Tetramer: Destabilized mRNA Complex AUF1 Dimer (isoform p37 or p40) AUF1(hnRNP D0) Dimers Bind AU-rich Element in 3' UTR of Transcripts AUF1 monomers form dimers which bind the U-rich sequences in AU-rich elements of mRNAs. Binding of the mRNA causes the dimers of AUF1 to form tetramers. Nonphosphorylated AUF1 isoform p40 causes the mRNA to form a rigid structure whereas p40 that is phosphorylated at serines 83 and 87 does not. This difference may cause nonphosphorylated p40 to fail to destabilize the bound mRNA. Authored: May, B, 2009-12-29 Edited: May, B, 2009-12-29 Pubmed10559216 Pubmed11124962 Pubmed12819194 Pubmed12819195 Pubmed12944492 Pubmed14976220 Pubmed15257295 Pubmed17486099 Pubmed18240226 Pubmed18573886 Pubmed19074427 Pubmed8246982 Pubmed9346902 Reactome Database ID Release 43450434 Reactome, http://www.reactome.org ReactomeREACT_24997 Reviewed: Wilusz, J, 2010-06-29 has a Stoichiometric coefficient of 2