Double-stranded RNA DICER:TRBP:duplex siRNA Dicer cleaves double-stranded RNA to yield double-stranded siRNA Authored: May, B, 2009-06-10 Dicer is an RNase III enzyme which cleaves double-stranded RNAs to yield short double-stranded RNAs of 21-25 nucleotides. Small interfering RNAs (siRNAs) are produced by Dicer and are similar to miRNAs in their final structure but differ from miRNAs in their source: siRNAs are produced from long double stranded RNAs that originate from viruses, transposable elements, centromeric repeats and other repetitive structures. EC Number: 3.1.26.3 Edited: May, B, 2009-06-10 Pubmed11201747 Pubmed12411504 Pubmed12411505 Pubmed15973356 Pubmed16142218 Pubmed16357216 Pubmed16424907 Pubmed17452327 Pubmed18178619 Pubmed20184375 Pubmed22163034 Reactome Database ID Release 43426464 Reactome, http://www.reactome.org ReactomeREACT_118784 Reviewed: Tomari, Y, 2012-02-10