Autointegration results in viral DNA circles Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 In this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are not substrates for integration.<br>It has been suggested that the cellular BAF protein binds to viral DNA and diminishes autointegration by coating and condensing the viral DNA, thereby making it a less efficient integration target.<br> Pubmed7937898 Pubmed9465049 Reactome Database ID Release 43177539 Reactome, http://www.reactome.org ReactomeREACT_6866 Reviewed: Bushman, FD, 2006-10-30 22:19:13 PathwayStep3531 PathwayStep3532 Suicidal integration leading to inverted circle formation Suicidal integration leading to smaller circles of viral DNA