Formation of the HIV-1 Early Elongation Complex Authored: Matthews, L, Rice, AP, 2005-07-27 00:00:00 Edited: Matthews, L, 2005-07-26 23:29:22 Pubmed11940650 Pubmed12370301 Pubmed12653964 Reactome Database ID Release 43167158 Reactome, http://www.reactome.org ReactomeREACT_6319 This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event. The details relevant to HIV-1 are described below. Formation of the early elongation complex involves hypophosphorylation of RNA Pol II CTD by FCP1P protein, association of the DSIF complex with RNA Pol II, and formation of DSIF:NELF:HIV-1 early elongation complex as described below (Mandal et al 2002; Kim et al 2003; Yamaguchi et al 2002). PathwayStep3557 PathwayStep3558 PathwayStep3559 PathwayStep3560 PathwayStep3561 DSIF complex binds to RNA Pol II (hypophosphorylated) Formation of DSIF:NELF:HIV-1 early elongation complex Abortive termination of HIV-1 early transcription elongation by DSIF:NELF Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex Hypophosphorylation of RNA Pol II CTD by FCP1P protein