Interactions of Vpr with host cellular proteins Host Interactions of HIV factors Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein. Reactome Database ID Release 43162909 Reactome, http://www.reactome.org ReactomeREACT_6288 Reviewed: Benarous, R, Zhao, RY, Peterlin, BM, 2006-10-30 22:12:28 APOBEC3G mediated resistance to HIV-1 infection Vif-mediated degradation of APOBEC3G Interactions of Rev with host cellular proteins The role of Nef in HIV-1 replication and disease pathogenesis Interactions of Tat with host cellular proteins Vpu mediated degradation of CD4 PathwayStep3622 PathwayStep3630 PathwayStep3634 PathwayStep3639 PathwayStep3640 PathwayStep3667 PathwayStep3673