Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Authored: Matthews, L, 2006-05-15 07:16:46 Edited: Matthews, L, 2006-06-02 10:55:44 In one model of Vpr mediated induction of apoptosis, Vpr acts directly on the mitochondrial permeability transition pore complex through its interaction with adenine nucleotide translocator (ANT). This interaction promotes the permeabiliztion of the mitochondrial membranes resulting in the release of cytochrome c and apoptosis-inducing factors. Pubmed10620603 Reactome Database ID Release 43180897 Reactome, http://www.reactome.org ReactomeREACT_8016 Reviewed: Zhao, RY, 2006-07-11 22:08:52 PathwayStep3616 PathwayStep3617 Association of Vpr with ANT1 Translocation of Vpr to the mitochondria