Nuclear import of Rev protein Authored: Matthews, L, 2006-06-08 06:14:23 Edited: Matthews, L, 2007-01-31 22:42:03 Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin β-B23 complex associates with the nuclear pore through interactions between importin β and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin β resulting in in the disassembly of the importin β-Rev-B23 complex and the release of Rev cargo. Reactome Database ID Release 43180746 Reactome, http://www.reactome.org ReactomeREACT_9395 Reviewed: Kumar, A, 2007-01-31 22:47:49 PathwayStep3627 PathwayStep3626 PathwayStep3625 PathwayStep3624 PathwayStep3623 PathwayStep3628 PathwayStep3599 Rev:importin beta:B23 recruited to the nuclear pore Rev associates with B23 Association of multimerized Rev with beta-importin Association of Ran-GTP with importin-beta Translocation of Rev:importin-beta:B23 to the nucleus Conversion of Ran-GDP to Ran-GTP Disassembly of the Rev-importin beta-B23:Ran-GTP complex