Classical Kir channels Authored: Mahajan, SS, 2011-05-18 Classical Kir channels are inwardly rectifying K+ channels with strong inwardly rectifying currents that contribute to highly negative resting membrane potential, prolonged action potential plateau and rapid repolarization in the final stage of action potential. Classical Kir channels are found in various cells such as cardiac myocytes, purkinje fibers, atrial and ventricular tissues. Rectification is caused by intracellular Mg2+ ions and polyamines. Edited: Mahajan, SS, 2011-05-23 Pubmed10599834 Reactome Database ID Release 431296053 Reactome, http://www.reactome.org ReactomeREACT_75870 Reviewed: Jassal, B, 2010-09-23 PathwayStep3399 Activation of classical Kir channels