Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Tandem pore domain potassium channels Authored: Mahajan, SS, 2011-05-19 Edited: Mahajan, SS, 2011-05-23 Pubmed20393194 Pubmed20529081 Reactome Database ID Release 431296346 Reactome, http://www.reactome.org ReactomeREACT_75897 Reviewed: Jassal, B, 2010-09-23 Tandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mechanisms such as membrane stretch, pH, temperature. Tandem pore domain K+ channels have been classified into six subfamilies; tandem pore domains in weak rectifying K+ channel (TWIK), TWIK-related K+ channel (TREK), TWIK-related acid-sensitive K+ channel (TASK), TWIK-related alkaline pH-activated K+ channel (TALK), tandem pore domain halothane-inhibted K+ channel (THIK), TWIK-releated spinal cord K+ channel). TWIK-releated acid-sensitive K+ channel (TASK) TWIK related potassium channel (TREK) TWIK-related spinal cord K+ channel (TRESK) TWIK-related alkaline pH activated K+ channel (TALK) Tandem pore domain halothane-inhibited K+ channel (THIK) PathwayStep3415 PathwayStep3413 PathwayStep3411 PathwayStep3405 PathwayStep3407 PathwayStep3409