TAK1 activates NFkB by phosphorylation and activation of IKKs complex Authored: Shamovsky, V, 2009-12-16 Edited: Shamovsky, V, 2011-08-12 GENE ONTOLOGYGO:0051092 NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression. Pubmed11460167 Pubmed15145317 Pubmed15837794 Reactome Database ID Release 43445989 Reactome, http://www.reactome.org ReactomeREACT_21281 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gillespie, ME, 2010-02-27 Reviewed: Napetschnig, Johanna, 2012-11-16 PathwayStep3436 PathwayStep3438 PathwayStep3437 Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex Activated TAK1 mediates phosphorylation of the IKK Complex Released NFkB complex is transported to nucleus