BoNT Light Chain Types A, C1, E cleave SNAP-25 Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 BoNTs of serotypes A, C1 and E cleave SNAP-25 (synaptosomal-associated protein, 25kDa), a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. BoNT A removes nine amino-acid residues from the carboxyl terminus, whereas BoNT E removes 26 C-terminal amino-acid residues (Bajohrs et al.,2004). Edited: Gopinathrao, G, 2006-06-15 22:12:29 Pubmed15486565 Pubmed8243676 Pubmed8294407 Pubmed8611567 Pubmed9886085 Reactome Database ID Release 43181546 Reactome, http://www.reactome.org ReactomeREACT_11240 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 PathwayStep3430 PathwayStep3429 PathwayStep3428 BoNT Light Chain Type E cleaves SNAP-25 BoNT Light Chain Type A cleaves SNAP-25 BoNT Light Chain Type C1 cleaves SNAP-25