ERK1 activation Activated MEK1 phosphorylates and activates ERK1. Authored: Charalambous, M, 2005-02-04 06:50:22 Edited: Schmidt, EE, 0000-00-00 00:00:00 Reactome Database ID Release 43110056 Reactome, http://www.reactome.org ReactomeREACT_1391 Reviewed: Greene, LA, 2007-11-08 15:39:37 PathwayStep3450 PathwayStep3451 PathwayStep3452 PathwayStep3453 PathwayStep3454 PathwayStep3455 Dimerisation of phospho-ERK-1 Dissociation of phospho-ERK-1:MEK1 Nuclear translocation of phospho-ERK-1 dimer Inactivation of MEK1 by p34cdc2 MEK1 phosphorylates ERK-1 MEK1 binds ERK-1