Uncoating of the HIV Virion Authored: Iordanskiy, S, Bukrinsky, M, 2006-04-03 16:17:37 Edited: Gopinathrao, G, 2006-02-17 18:35:46 GENE ONTOLOGYGO:0019061 HIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, the primary cause seems to be the cytosolic pH and a simple dilution effect. Successful uncoating generates the viral reverse transcription complex, which comprises the diploid viral RNA genome, tRNALys primer, RT, IN, MA, nucleocapsid (NC), viral protein R (Vpr) and various host proteins; the reverse-transcription complex is thus liberated from the plasma membrane. It is believed that the transiting viral nucleoprotein complex associates with the elements of cytoskeleton like actin microfilaments. Pubmed12091904 Pubmed12417576 Pubmed15502876 Pubmed15700618 Reactome Database ID Release 43162585 Reactome, http://www.reactome.org ReactomeREACT_6965 Reviewed: Aiken, C, 2006-10-30 22:04:39 Disintegration of matrix layer Disassembly of viral capsid PathwayStep3498 PathwayStep3499