p-T-2S-SMAD2/3:SMAD4:SMURF2 p-T,2S-SMAD2/3:SMAD4 SMURF2 binds SMAD3 phosphorylated in the linker region Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 Pubmed22045334 Reactome Database ID Release 432179274 Reactome, http://www.reactome.org ReactomeREACT_121396 Reviewed: Huang, Tao, 2012-05-14 SMURF2 binds SMAD2/3:SMAD4 heterotrimer through ineraction with SMAD3. Phosphorylation of threonine T179 in the linker region of SMAD3 is critical for SMURF2 binding. SMURF2 also interacts with SMAD2 phosphorylated in the linker region.