p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL After phosphorylated SMAD2/3 accumulate in the nucleus in response to TGF-beta stimulation, E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007) and SMURF2 (Bonni et al. 2001) bind SKI/SKIL in complex with SMAD2/3:SMAD4 heterotrimer. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL (Levy et al. 2007). The role of SMURF2 was inferred from experiments involving human proteins only (Bonni et al. 2001). Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 Pubmed11389444 Pubmed17591695 Reactome Database ID Release 432186741 Reactome, http://www.reactome.org ReactomeREACT_121054 Reviewed: Huang, Tao, 2012-05-14 RNF111/SMURF2