capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex TFIIH RNA Pol II (hypophosphorylated):capped pre-mRNA complex Hypophosphorylation of RNA Pol II CTD by FCP1P protein Authored: Gopinathrao, G, 2004-04-28 10:54:00 EC Number: 3.1.3.16 FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and, therefore, is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE). Pubmed12370301 Reactome Database ID Release 43112383 Reactome, http://www.reactome.org ReactomeREACT_1251