RNA Polymerase III Holoenzyme TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex RNA Polymerase III:TFIIIB:SNAPc:Type 3 Promoter Complex Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex Authored: Hernandez, N, 2003-09-11 07:42:29 Edited: Gillespie, ME, 0000-00-00 00:00:00 Pubmed11564744 Pubmed12016223 Pubmed12391172 Pubmed12621023 Pubmed9027316 Reactome Database ID Release 4383803 Reactome, http://www.reactome.org ReactomeREACT_254 The binding of SNAPc to the PSE is stabilized not only by cooperative interactions with the Oct-1 POU domain, but also by cooperative interactions with TBP and Brf2 (Hinkley et al., 2003 ; Ma and Hernandez, 2002; Mittal and Hernandez, 1997). Moreover, Brf2, which cannot bind to DNA on its own, recognizes and stabilizes TBP bound to the TATA box (Cabart and Murphy, 2001; Cabart and Murphy, 2002; Ma and Hernandez, 2002). Thus, the U6 transcription initiation complex is stabilized by a complex network of protein-protein and protein-DNA interactions. Nothing is known, however, about how the complex recruits RNA polymerase III.