mTERF:mitochondrial transcription termination sequence mitochondrial transcription termination sequence Association of mTERF with the termination sequence Authored: Gustafsson, C, 2005-04-25 22:00:00 Edited: Matthews, L, 0000-00-00 00:00:00 Pubmed11713324 Pubmed2752429 Pubmed7525579 Pubmed7681833 Pubmed9118945 Reactome Database ID Release 43163320 Reactome, http://www.reactome.org ReactomeREACT_2027 Reviewed: Cantatore, P, 0000-00-00 00:00:00 The 39-kDa mitochondrial transcription termination factor (mTERF), binds to a 28-base pair region of mtDNA (3237-3249) located within the tRNALeu(UUR) gene, at a position immediately downstream of the rRNA 16S gene (Fernandez-Silva et al., 1997; Kruse et al., 1989; Daga et al., 1993). mTERF binding to the termination sequence block transcription bidirectionally in a partially purified human mitochondrial system (Shang and Clayton, 1994). A polar termination activity has been also observed for the sea urchin homologue of mTERF, referred to as mtDBP with respect of phage RNA polymerases (Fernandez Silva et al. 2001).