vRNP Export through the nuclear pore Binding of vRNP:M1:NEP complex to CRM1 export receptor NEP/NS2 Interacts with the Cellular Export Machinery Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 GENE ONTOLOGYGO:0046796 Pubmed11118210 Pubmed12970177 Pubmed17081640 Pubmed1913813 Pubmed9427762 Reactome Database ID Release 43168333 Reactome, http://www.reactome.org ReactomeREACT_6179 Reviewed: Squires, B, 2007-02-12 19:39:22 The viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 to form an export complex. Rather, an additional viral protein, nuclear export protein (NEP/NS2), acts as an adaptor, binding the viral matrix M1 protein and CRM1, thus linking the viral RNP with CRM1 (Martin, 1991; O'Neill, 1998; Neumann, 2000; Akarsu, 2003). The CRM1/exportin-1 complex recruits additional host cell proteins, and traverses the nuclear pore into the cytosol. PathwayStep3718 PathwayStep3717