Packaging of Eight RNA Segments Budding Virus Assembly and Release GENE ONTOLOGYGO:0019067 Influenza viruses assemble and bud from the apical plasma membrane of polarized cells e.g. lung epithelial cells of the infected host. This asymmetrical process (i.e. apical [Influenza virus] or basolateral [Marburg virus]) is thought to have an important role in viral pathogenesis and tissue tropism. In most cases the individual viral envelope proteins are seen to accumulate at the same polar surface from which virus budding occurs, suggesting that they determine the maturation site Pubmed0 Pubmed16139601 Pubmed283416 Reactome Database ID Release 43168268 Reactome, http://www.reactome.org ReactomeREACT_6270 Assembly of Viral Components at the Budding Site Release PathwayStep3746 PathwayStep3744 PathwayStep3742 PathwayStep3739