NEP/NS2 Interacts with the Cellular Export Machinery Export of Viral Ribonucleoproteins from Nucleus Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 GENE ONTOLOGYGO:0046796 Influenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP trimers bind the sugar phosphate backbone of the vRNA. As influenza viral RNP complexes are too large for passive diffusion out of the nucleus, utilization of the cellular nuclear export machinery is achieved by viral adaptor proteins. Matrix protein (M1) is critical for export of the complex from the nucleus, mediating the interaction of the RNP complex with the viral NEP/NS2 protein, which in turn interacts with host cell CRM1/exportin-1 nuclear export protein (Martin, 1991; O'Neill, 1998; Neumann et al., 2000; Elton, 2001; Cros, 2003; Ye, 2006; reviewed in Boulo, 2006). Pubmed11118210 Pubmed11119609 Pubmed16806605 Pubmed17081640 Reactome Database ID Release 43168274 Reactome, http://www.reactome.org ReactomeREACT_6296 Reviewed: Squires, B, 2007-02-12 19:39:22 Viral RNP Complexes in the Host Cell Nucleus PathwayStep3719 PathwayStep3716