cRNA Synthesis Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 Pubmed10438824 Pubmed15163719 Pubmed15308750 Pubmed15557242 Pubmed16474140 Pubmed2453679 Reactome Database ID Release 43192869 Reactome, http://www.reactome.org ReactomeREACT_9527 Reviewed: Squires, B, 2007-02-12 19:39:22 Synthesis of full length complementary viral RNA (cRNA) requires that vRNA transcription initiates without the help of a host cell methyl RNA cap as a primer (Crow, 2004; Vreede, 2004; Deng, 2006), and that it proceeds to the 5' end of the vRNA template without stuttering on the sub-terminal poly-U sequence. Free viral NP protein appears to play a central role in enabling both of these features of cRNA synthesis, although the molecular details of its role remain unclear (Shapiro, 1988; Medcalf, 1999; Mullin, 2004). PathwayStep3703 PathwayStep3704 Initiation of cRNA Synthesis cRNA Extension