Active PLC-gamma1 dissociates from EGFR Phospholipase C-gamma1 binds to the activated EGF receptor EGFR activates PLC-gamma1 by phosphorylation EGFR interacts with phospholipase C-gamma Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation. Authored: Jassal, B, 2008-02-13 11:13:12 GENE ONTOLOGYGO:0007165 Pubmed1501243 Reactome Database ID Release 43212718 Reactome, http://www.reactome.org ReactomeREACT_12478 Reviewed: Heldin, CH, 2008-02-12 09:44:02 DAG and IP3 signaling PathwayStep3822 PathwayStep3823 PathwayStep3821 PathwayStep3841