DAG stimulates protein kinase C-delta Active PLCG1 hydrolyses PIP2 IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel Release of calcium from intracellular stores by IP3 receptor activation PathwayStep2071 PathwayStep2072 DAG and IP3 signaling Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Pubmed16260143 Reactome Database ID Release 431489509 Reactome, http://www.reactome.org ReactomeREACT_111064 Reviewed: Greene, LA, 2007-11-08 15:39:37 This pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events. CaM pathway PathwayStep3824 PathwayStep3825 PathwayStep3840