Peroxynitrite is reduced by AhpE Peroxynitrite is reduced to nitrite by AhpC Nitric oxide is oxidized to nitrate Nitrogen dioxide is reduced to NO by F420 Mycothiol scavenges nitrosyl Peroxynitrite is reduced to nitrite by Tpx MsrA/B reduces peptide-methionine S/R-sulfoxides MscR reduces nitrosomycothiol to ammonia Nitrosoglutathione gets cleaved to Cys(NO)-Gly Tolerance by Mtb to nitric oxide produced by macrophages Authored: Stephan, R, 2011-01-10 Edited: Jassal, B, 2011-02-28 GENE ONTOLOGYGO:0052060 Pubmed15378046 Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and <i>Mtb</i> has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages.<br><i>Mtb</i> repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004). Reactome Database ID Release 431222538 Reactome, http://www.reactome.org ReactomeREACT_120983 Reviewed: Warner, D, 2012-04-30 PathwayStep3787 PathwayStep3785 PathwayStep3786 PathwayStep3782 PathwayStep3781 PathwayStep3784 PathwayStep3783 PathwayStep3780 PathwayStep3779