H2O2 gets scavenged by unsaturated lipid AhpC reduces peroxidated lipids SodB gets secreted SodC reduces superoxide to H2O2 SodB reduces superoxide to H2O2 KatG reduces H2O2 AhpC reduces H2O2 Tolerance of reactive oxygen produced by macrophages Authored: Stephan, R, 2011-01-10 Edited: Jassal, B, 2011-02-28 GENE ONTOLOGYGO:0052059 Pubmed11970850 Reactome Database ID Release 431222387 Reactome, http://www.reactome.org ReactomeREACT_121009 Reviewed: Warner, D, 2012-04-30 The expression of <i>AhpC</i> in Mycobacteria does not correlate with virulence; instead, the most important parts of the antioxidant system in <i>Mtb</i> appear to be the lipid cell wall, the enzymes SodB/SodC (superoxide dismutases), and the catalase/peroxidase KatG. Together with the enzyme system that acts on nitrosative stress and the sequestration of iron, these appear to be critical in defending against the macrophage's production of ROS/RNS, and enable the bacterium to exist in the phagosome for extended periods (Zahrt & Deretic 2002). PathwayStep3795 PathwayStep3794 PathwayStep3793 PathwayStep3792 PathwayStep3791 PathwayStep3790 PathwayStep3789