Lpd reactivates dlaT DlaT reactivates AhpD AhpD reactivates AhpC Fgd1 reactivates F420 TrxA/B1 reactivates Tpx TrxB reactivates TrxA TrxA reactivates AhpC Cell redox homeostasis Authored: Stephan, R, 2011-01-10 Edited: Jassal, B, 2011-02-28 GENE ONTOLOGYGO:0045454 Pubmed17012768 Pubmed21270886 Reactome Database ID Release 431222541 Reactome, http://www.reactome.org ReactomeREACT_121394 Reviewed: Warner, D, 2012-04-30 The most important response of <i>Mtb</i> to oxidative stress is provided by catalase and peroxiredoxins, both of which get their reducing equivalents through a network of disulfide proteins and, finally, from NAD(P)H. Multiple redundancies make choosing a good drug target difficult (Koul et al. 2011). Optimum efficacy can only be expected from inhibitors of the most upstream components of the redox cascades, i.e. the NAD(P)H-dependent reductases TrxB and Lpd (Jaeger & Flohe 2006). PathwayStep3797 PathwayStep3798 PathwayStep3799 PathwayStep3801 PathwayStep3800 PathwayStep3803 PathwayStep3802