Glutathione is taken up by the bacterium Glutathione scavenges nitrosyl Peroxynitrite oxidizes methionine residues Cathelicidin LL-37 localizes to bacterial cell wall NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages Lactoferrin scavenges iron ions Nitric oxide oxidizes to nitrosyl Hydroperoxyl enters the bacterium Protonation of superoxide Peroxynitrite enters the bacterium Superoxide and nitric oxide react to peroxynitrite Nitric oxide enters the bacterium Nitric oxide diffuses into the phagosome Intraphagosomal pH is lowered to 5 by V-ATPase NOX2 generates superoxide from oxygen PathwayStep526 Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) Phagosomal maturation (early endosomal stage) Alveolar macrophages normally develop their phagosome along the endolysosomal pathway. However, after having internalized <i>Mtb</i>, this development is arrested at an early stage and only includes acidification, nitric oxide and superoxide production, as well as the use of a few other proteins that can be gained from other endosomes which still can interact with the phagosome (Flannagan et al. 2009). Authored: Stephan, R, 2011-01-10 Edited: Jassal, B, 2011-02-28 GENE ONTOLOGYGO:0090382 Pubmed19369951 Reactome Database ID Release 431222556 Reactome, http://www.reactome.org ReactomeREACT_121256 Reviewed: Warner, D, 2012-04-30 PathwayStep3774 PathwayStep3775 PathwayStep3776 PathwayStep3777 PathwayStep3772 PathwayStep3773 PathwayStep3770 PathwayStep3771 PathwayStep3766 PathwayStep3765 PathwayStep3764 PathwayStep3763 PathwayStep3769 PathwayStep3768 PathwayStep3767