Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) Binding of NS1 to poly(A)-binding protein II (PABII) Inhibition of Host mRNA Processing and RNA Silencing GENE ONTOLOGYGO:0046778 Pubmed10205180 Pubmed7958859 Pubmed8313914 Reactome Database ID Release 43168315 Reactome, http://www.reactome.org ReactomeREACT_6173 The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. NS1 also inhibits the splicing of pre-mRNAs, resulting in their retention within the host cell nucleus. PathwayStep3750 PathwayStep3749