Nef mediated downregulation of MHC class I complex cell surface expression Authored: Gillespie, ME, 2007-07-25 19:42:36 Down-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sorting pathway. Down-regulation of MHC I protects HIV-infected cells from host CTL response. GENE ONTOLOGYGO:0050690 Pubmed10707087 Pubmed11593029 Pubmed12414957 Pubmed12526811 Pubmed15569716 Pubmed8612235 Pubmed9586638 Reactome Database ID Release 43164940 Reactome, http://www.reactome.org ReactomeREACT_11103 Reviewed: Skowronski, J, 2007-08-07 14:33:41 PathwayStep3651 PathwayStep3652 PathwayStep3653 PathwayStep3654 Transport of MHC I:Nef:AP-1:PACS-1 Complex Degradation of MHC I Complex Formation of MHC I:Nef Complex Formation of MHC I:Nef:AP-1:PACS-1 Complex