PathwayStep4104 PathwayStep4107 Klotho-mediated ligand binding Authored: Rothfels, K, 2011-08-15 Pubmed17339340 Pubmed19063940 Reactome Database ID Release 431307973 Reactome, http://www.reactome.org ReactomeREACT_111247 Reviewed: Gotoh, N, 2011-08-26 The endocrine FGFs (19, 21 and 23) have lower affinity for heparin and HSPG compared to their paracrine or autocrine coutnerparts. Binding of these ligands to their receptors is generally aided by the FGF-binding Klotho proteins. betaKlotho-mediated ligand binding FGFR1c and Klotho ligand binding and activation