PathwayStep4103 PathwayStep4102 Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 FGFR4 binds BetaKlotho-bound FGF19 betaKlotho-mediated ligand binding Authored: Rothfels, K, 2011-08-15 FGF21 and FGF19 require betaKlotho for efficient signaling through FGFR1c and FGFR3c. betaKlotho does not interact with 'b' receptor isoforms, and only weakly with FGFR2c. In addition, FGF19, but not FGF21, signals through FGFR4 in a betaKlotho-dependent fashion Pubmed17623664 Pubmed19063940 Reactome Database ID Release 431307965 Reactome, http://www.reactome.org ReactomeREACT_111046 Reviewed: Gotoh, N, 2011-08-26