PathwayStep4105 PathwayStep4106 FGFR1c binds to Klotho-bound FGF23 Autocatalytic phosphorylation of Klotho-bound FGFR1c FGFR1c and Klotho ligand binding and activation Authored: de Bono, B, 2007-01-10 10:27:18 FGF23 is a member of the endocrine subfamily of FGFs. It is produced in bone tissue and regulates kidney functions. Klotho is essential for endogenous FGF23 function as it converts FGFR1c into a specific FGF23 receptor. GENE ONTOLOGYGO:0008543 Pubmed16436388 Pubmed17086194 Reactome Database ID Release 43190374 Reactome, http://www.reactome.org ReactomeREACT_9484 Reviewed: Mohammadi, M, 2007-02-06 21:44:35