PathwayStep4067 PathwayStep4066 PathwayStep4065 IGF2BP3 Binds Specific RNA Molecules IGF2BP2 Binds Specific RNA Molecules IGF2BP1 Binds Specific RNA Molecules Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Authored: May, B, 2009-07-04 Edited: May, B, 2009-07-04 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation, stability, and subcellular localization. IGF2BP1, IGF2BP2, and IGF2BP3 bind about 8400 protein-coding transcripts. The target RNAs contain the sequence motif CAUH (where H is A, U, or, C) and binding of IGFBPs increases the stability of the target RNAs. Pubmed11713986 Pubmed15601260 Pubmed16541107 Pubmed17652133 Pubmed20371350 Pubmed9891060 Reactome Database ID Release 43428359 Reactome, http://www.reactome.org ReactomeREACT_22166 Reviewed: Chao, JA, 2010-05-30 Reviewed: Singer, RH, 2010-05-30