PathwayStep4009 PathwayStep4006 PathwayStep4005 PathwayStep4008 PathwayStep4007 PathwayStep4012 PathwayStep4013 PathwayStep4014 PathwayStep4015 PathwayStep4010 PathwayStep4011 PathwayStep4019 PathwayStep4018 PathwayStep4017 PathwayStep4016 PathwayStep4025 PathwayStep4026 PathwayStep4023 PathwayStep4024 PathwayStep4021 PathwayStep4022 PathwayStep4020 PathwayStep4000 PathwayStep4003 PathwayStep4004 PathwayStep4001 PathwayStep4002 PathwayStep4033 PathwayStep4032 PathwayStep4031 PathwayStep4030 PathwayStep4035 PathwayStep4034 PathwayStep4029 PathwayStep4027 PathwayStep4028 Expression of DDX11 Expression of DCTN1 Expression of DNAJB9 Expression of DNAJB11 Expression of EXTL3 Expression of EDEM Expression of ARFGAP1 (GAP) Expression of FKBP14 Expression of Cullin-7 Expression of CXXC1 Expression of CTDSP2 Expression of C19orf10 Expression of ATP6VOD1 Expression of ADD1 (Adducin alpha) Expression of ACADVL Expression of Sec12 Expression of SYVN1 (HRD1) Expression of SRPRB (SRP Receptor subunit beta) Expression of SRPR (SRP Receptor subunit alpha) Expression of SULT1A3 Expression of SSR1 (Trap alpha) Expression of PPP2R5B Expression of PLA2G4B Expression of SHC1 Expression of SERP1 (RAMP4) Expression of PDIA6 (Protein disulfide-isomerase A6) Expression of PDIA5 Expression of LMNA Expression of KLHDC3 Expression of KDELR3 Expression of HYOU1 Expression of HDGF Expression of GSK3A Expression of GOSR2 Expression of GFPT1 Expression of Sec31A Expression of TATDN2 Expression of TPP1 Expression of TSPYL2 Expression of Talin-1 Expression of WFS1 Expression of WIPI1 Expression of YIF1A Expression of ZBTB17 Expression of DNAJC3 (p58IPK) Activation of Chaperone Genes by XBP1(S) Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 Pubmed14559994 Pubmed16461360 Pubmed16539657 Pubmed17612490 Pubmed18664523 Reactome Database ID Release 43381038 Reactome, http://www.reactome.org ReactomeREACT_18273 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER. PathwayStep3994 PathwayStep3995 PathwayStep3996 PathwayStep3997 PathwayStep3998 PathwayStep3999 PathwayStep3993 PathwayStep3992 PathwayStep3991