Expression of Xbp1(S) Expression of HSP90B1 (Endoplasmin) Expression of Calreticulin Expression of CHOP (DDIT3, GADD153) Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) Activation of Chaperone Genes by ATF6-alpha Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 Pubmed10856300 Pubmed10866666 Pubmed10958673 Pubmed14973138 Reactome Database ID Release 43381183 Reactome, http://www.reactome.org ReactomeREACT_18423 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins. PathwayStep3978 PathwayStep3979 PathwayStep3980 PathwayStep3982 PathwayStep3981