PathwayStep4080 PathwayStep4083 FGFR1c ligand binding and activation FGFR1b ligand binding and activation FGFR1 ligand binding and activation Authored: de Bono, B, 2007-01-10 10:27:18 Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22 GENE ONTOLOGYGO:0008543 Pubmed12141425 Pubmed12791257 Pubmed16045455 Pubmed16597617 Reactome Database ID Release 43190242 Reactome, http://www.reactome.org ReactomeREACT_9483 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.<br><br>FGFR is probably activated by NCAM very differently from the way by which it is activated by FGFs, reflecting the different conditions for NCAM–FGFR and FGF–FGFR interactions. The affinity of FGF for FGFR is approximately 10e6 times higher than that of NCAM for FGFR. Moreover, in the brain NCAM is constantly present on the cell surface at a much higher (micromolar) concentration than FGFs, which only appear transiently in the extracellular environment in the nanomolar range.