Dimerisation of CREB PKA catalytic subunit translocates to the nucleus PKA phosphorylates CREB PKA activation PKA-mediated phosphorylation of CREB Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Cyclic adenosine 3',5'-monophosphate (cAMP) induces gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133. Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed15337521 Pubmed16125054 Reactome Database ID Release 43111931 Reactome, http://www.reactome.org ReactomeREACT_15497 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 PathwayStep3827 PathwayStep3828 PathwayStep3829 PathwayStep3830