Calmodulin activates Cam-PDE 1 cAMP hydrolysis by Cam-PDE 1 Cam-PDE 1 activation Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Human Ca2+/calmodulin-dependent phosphodiesterase PDE1 is activated by the binding of calmodulin in the presence of Ca(2+). PDE1 has three subtypes PDE1A, PDE1B and PDE1C and their role is to hydrolyze both cGMP and cAMP. Their role is to antagonize the increased concentration of the intracellular second messengers determined by the synthetic activity of the adenylate cyclase enzymes thus governing intracellular cAMP dynamics in response to changes in the cytosolic Ca2+ concentration. PDE1 are mainly cytosolic but different isoforms are expressed in different tissues. Pubmed10442095 Pubmed16786160 Reactome Database ID Release 43111957 Reactome, http://www.reactome.org ReactomeREACT_15408 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 PathwayStep3835 PathwayStep3834