Dimerisation of CREB CaMK IV phosphorylates CREB CaMK IV-mediated phosphorylation of CREB Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed10366852 Reactome Database ID Release 43111932 Reactome, http://www.reactome.org ReactomeREACT_15502 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 The Ca2+-calmodulin-dependent protein kinase (CaM kinase) cascade includes three kinases: CaM-kinase kinase (CaMKK); and the CaM kinases CaMKI and CaMKIV, which are phosphorylated and activated by CaMKK. Members of this cascade respond to elevation of intracellular Ca2+ levels. CaMKK and CaMKIV localize both to the nucleus and to the cytoplasm, whereas CaMKI is only cytosolic. Nuclear CaMKIV regulates transcription through phosphorylation of several transcription factors, including CREB. In the cytoplasm, there is extensive cross-talk between CaMKK, CaMKIV and other signaling cascades, including those that involve the cAMP-dependent kinase (PKA), MAP kinases and protein kinase B (PKB/Akt). PathwayStep3347 PathwayStep3348 PathwayStep3349 CaMK IV autophosphorylation CamKIV enters the nucleus Calmodulin binds CaMK IV PathwayStep3832 PathwayStep3830