ERK activation MEK activation RAF activation RAF/MAP kinase cascade Authored: Charalambous, M, 2004-04-29 09:21:24 GENE ONTOLOGYGO:0000165 Pubmed15520807 Pubmed17496910 Reactome Database ID Release 43109869 Reactome, http://www.reactome.org ReactomeREACT_634 Reviewed: Greene, LA, 2007-11-08 15:39:37 The MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a common 'module' in the transmission of an extracellular signal into the nucleus. PathwayStep3463 PathwayStep3856 PathwayStep3851