AKT phosphorylates AKT1S1 (PRAS40) AKT phosphorylates IKKalpha AKT phosphorylates MDM2 AKT phosphorylates TSC2, inhibiting it AKT phosphorylates p21Cip1 and p27Kip1 AKT phosphorylates BAD AKT phosphorylates caspase-9 AKT phosphorylates GSK3 AKT phosphorylates targets in the cytosol Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2011-05-11 Following activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kinase, which, in turn, contributes to AKT activation (positive feedback loop). Reactome Database ID Release 43198323 Reactome, http://www.reactome.org ReactomeREACT_12564 Reviewed: Greene, LA, 2007-11-08 15:39:37 PathwayStep3880 PathwayStep3881 PathwayStep3882 PathwayStep3876 PathwayStep3875 PathwayStep3878 PathwayStep3877 PathwayStep3879