SHC1 phosphorylation by phosphorylated EGFR SHC1 binds to the phosphorylated EGF receptor:ligand complex SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR RAF/MAP kinase cascade SHC1 events in EGFR signaling Authored: Castagnoli, L, 2006-10-10 13:09:34 GRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation. Pubmed11498013 Pubmed8755247 Reactome Database ID Release 43180336 Reactome, http://www.reactome.org ReactomeREACT_12579 Reviewed: Heldin, CH, 2008-02-12 09:44:02 PathwayStep3862 PathwayStep3860 PathwayStep3861 PathwayStep3857 PathwayStep3859