PTEN dephosphorylates PIP3 PHLPP dephosphorylates S473 in AKT THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation Negative regulation of the PI3K/AKT network Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Reactome Database ID Release 43199418 Reactome, http://www.reactome.org ReactomeREACT_12447 Reviewed: Greene, LA, 2007-11-08 15:39:37 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 The PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation. PathwayStep3890 PathwayStep3891 PathwayStep3892